Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25617637 | 0.96 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2HTTCYP1A2CYP3A4 | |
| SCHEMBL21410445 | 0.96 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2HTTCYP1A2CYP3A4 | |
| SCHEMBL25617642 | 0.94 | L3MBTL1 (0.46) | ALDH1A1SMN1; SMN2HTTCYP1A2CYP3A4 | |
| SCHEMBL23245063 | 0.93 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2HTTCYP1A2CYP3A4 | |
| SCHEMBL21410815 | 0.93 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2HTTCYP1A2CYP3A4 | |
| SCHEMBL25617602 | 0.92 | MAPT (0.48) | ALDH1A1SMN1; SMN2HTTCYP1A2CYP3A4 | |
| SCHEMBL21410329 | 0.92 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2HTTCYP1A2CYP3A4 | |
| SCHEMBL21416253 | 0.90 | L3MBTL1 (0.49) | ALDH1A1SMN1; SMN2HTTCYP1A2CYP3A4 | |
| SCHEMBL25617604 | 0.90 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2HTTCYP1A2CYP3A4 | |
| SCHEMBL25617651 | 0.90 | HTT (0.49) | ALDH1A1SMN1; SMN2HTTCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11661404-B2 | Prodrug compounds activated by AKR1C3 and their use for treating hyperproliferative disorders | ACHILLES MEDICAL LIMITED (NZ) | 2023-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11661404-B2 | Prodrug compounds activated by AKR1C3 and their use for treating hyperproliferative disorders | AKR1C2, AKR1C1, AKR1B1 | ALDH1A1 61/4885SMN1; SMN2 4208/4885HTT 4808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.