SCHEMBL25618878

SCHEMBL25618878

Cc1cncnc1C(F)F

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 3/20 0.35
CYP11B2 P19099 3/20 0.35
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
PRKDC P78527 2/20 0.30
KCNH2 Q12809 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2742981 0.79 CYP11B1 (0.35) CYP11B1CYP11B2CYP1A2CYP3A4CYP2D6
SCHEMBL13844566 0.76 CYP1A2 (0.30) CYP1A2CYP3A4CYP2D6
SCHEMBL31214086 0.74 CYP11B1 (0.39) CYP11B1CYP11B2CYP3A4
SCHEMBL29324345 0.74 P2RX3 (0.34) CYP11B1CYP11B2
SCHEMBL28305894 0.73 CYP11B1 (0.33) CYP11B1CYP11B2
SCHEMBL29652983 0.73 CYP11B1 (0.33) CYP11B1CYP11B2
SCHEMBL31214084 0.73 CYP11B1 (0.33) CYP11B1CYP11B2
SCHEMBL19743786 0.73 CYP11B1 (0.33) CYP11B1CYP11B2
SCHEMBL12673791 0.72
SCHEMBL13028949 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11771738-B2 Endoparasitic depsipeptides ZOETIS SERVICES LLC (US) 2023-10-03 US disclosed
US-11771738-B2 Endoparasitic depsipeptides ZOETIS SERVICES LLC (US) 2023-10-03 US disclosed
US-20230167062-A1 AMIDE COMPOUND CONTAINING SUBSTITUTED ACETOPHENONE STRUCTURAL FRAGMENTS AND PREPARATION METHOD AND APPLICATION THEREOF SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD. (CN) 2023-06-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230167062-A1 AMIDE COMPOUND CONTAINING SUBSTITUTED ACETOPHENONE STRUCTURAL FRAGMENTS AND PREPARATION METHOD AND APPLICATION THEREOF AADAC, AAK1, ACLY CYP11B1 1485/4885CYP11B2 1596/4885CYP1A2 1033/4885
US-11771738-B2 Endoparasitic depsipeptides VIP, PREP, VIPR1 CYP11B1 1357/4885CYP11B2 1325/4885CYP1A2 1888/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.