Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18814368 | 0.88 | ALDH1A1 (0.49) | SMN1; SMN2LMNAKMT2AALDH1A1HPGD | |
| SCHEMBL18811817 | 0.88 | ALDH1A1 (0.49) | SMN1; SMN2LMNAKMT2AALDH1A1HPGD | |
| SCHEMBL21261925 | 0.88 | ALDH1A1 (0.49) | SMN1; SMN2LMNAKMT2AALDH1A1HPGD | |
| SCHEMBL20626544 | 0.74 | ITGB1 (0.36) | SMN1; SMN2LMNAALDH1A1EPHX2THRB | |
| SCHEMBL21261915 | 0.74 | SMYD3 (0.39) | SMN1; SMN2LMNAKMT2AALDH1A1HPGD | |
| SCHEMBL30416885 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAKMT2AALDH1A1EPHX2 | |
| SCHEMBL23323337 | 0.71 | EPHX2 (0.40) | SMN1; SMN2EPHX2 | |
| SCHEMBL23323338 | 0.71 | EPHX2 (0.40) | SMN1; SMN2EPHX2 | |
| SCHEMBL23552243 | 0.71 | EPHX2 (0.40) | SMN1; SMN2EPHX2 | |
| SCHEMBL23566950 | 0.71 | EPHX2 (0.40) | SMN1; SMN2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3368088-B1 | COMPOSITIONS AND METHODS FOR TREATMENT OF PEROXISOMAL DISORDERS AND LEUKODYSTROPHIES | UNIV JOHNS HOPKINS (US) | 2023-06-07 | — | — | EP | disclosed |