Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21468508 | 0.92 | SIRT6 (0.50) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL28834758 | 0.81 | MAPT (0.52) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL12604704 | 0.79 | PDGFRB (0.56) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL25228537 | 0.79 | DTYMK (0.50) | TDP1MAPTALDH1A1 | |
| SCHEMBL31006894 | 0.79 | DTYMK (0.50) | TDP1MAPTALDH1A1 | |
| SCHEMBL3898466 | 0.78 | TDP1 (0.54) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL2897709 | 0.78 | PDGFRB (0.67) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL4097915 | 0.78 | PDGFRB (0.55) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL2722464 | 0.78 | PDGFRB (0.51) | SIRT6PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL1640894 | 0.78 | SIRT6 (0.48) | SIRT6PDGFRBFGFR1PDGFRAFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023114819-A1 | TETRALINE, PHENYLCYCLOBUTANE, AND PHENYLCYCLOPENTANE ANALOGS AS RXFP1 AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-06-22 | — | — | WO | disclosed |