Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 6/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30353531 | 0.71 | PRKDC (0.44) | PRKDCRAD52PIK3CAPIK3CDPIK3CB | |
| SCHEMBL25618870 | 0.71 | PRKDC (0.44) | PRKDCRAD52PIK3CAPIK3CDPIK3CB | |
| SCHEMBL30353540 | 0.71 | PRKDC (0.44) | PRKDCRAD52PIK3CAPIK3CDPIK3CB | |
| SCHEMBL30353557 | 0.70 | RAD52 (0.44) | PRKDCRAD52PIK3CAPIK3CDPIK3CB | |
| SCHEMBL25626207 | 0.70 | RAD52 (0.44) | PRKDCRAD52PIK3CAPIK3CDPIK3CB | |
| SCHEMBL4121103 | 0.67 | PIK3CA (0.53) | PRKDCRAD52PIK3CAPIK3CDPIK3CB | |
| SCHEMBL30353552 | 0.64 | PIK3CD (0.44) | PRKDCRAD52PIK3CAPIK3CDPIK3CB | |
| SCHEMBL25626249 | 0.64 | PIK3CD (0.44) | PRKDCRAD52PIK3CAPIK3CDPIK3CB | |
| SCHEMBL31547941 | 0.64 | PIK3CA (0.63) | PRKDCPIK3CA | |
| SCHEMBL25617735 | 0.64 | PIK3CA (0.63) | PRKDCPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107623-A2 | BICYCLIC HETEROARENES AND METHODS OF THEIR USE | Kineta, Inc. (US) | 2023-06-15 | — | — | WO | disclosed |