Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | LITAF | Q99732 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 3/20 | 0.31 |
| ▸ | PDE8B | O95263 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2558109 | 0.97 | PDE10A (0.44) | PDE10APOLBTP53TNFLITAF | |
| SCHEMBL2564284 | 0.84 | PDE10A (0.54) | PDE10APOLBPDE4APDE4BPDE4C | |
| SCHEMBL2556902 | 0.82 | PDE10A (0.54) | PDE10APOLBTP53PDE4APDE4B | |
| SCHEMBL2563205 | 0.82 | PDE10A (0.53) | PDE10APOLBTP53PDE4APDE4B | |
| SCHEMBL2559772 | 0.82 | PDE10A (0.53) | PDE10APOLBTP53PDE4APDE4B | |
| SCHEMBL8272011 | 0.81 | PDE10A (0.62) | PDE10APOLBTP53PDE4APDE4B | |
| SCHEMBL2575117 | 0.76 | PDE10A (0.52) | PDE10APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2557912 | 0.76 | PDE10A (0.46) | PDE10APOLBTP53 | |
| SCHEMBL2560611 | 0.76 | PDE4A (0.42) | PDE10ATNFPDE4APDE4BPDE4C | |
| SCHEMBL2575124 | 0.75 | PDE10A (0.55) | PDE10APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |