Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | UBE2M | P61081 | 8/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 8/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2564244 | 0.86 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2KMT2AGAALMNA | |
| SCHEMBL2561460 | 0.83 | MAPT (0.44) | ALDH1A1SMN1; SMN2KMT2AGAALMNA | |
| SCHEMBL2564775 | 0.76 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2KMT2AGAALMNA | |
| SCHEMBL2551906 | 0.75 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2KMT2AGAALMNA | |
| SCHEMBL2564076 | 0.75 | SMN1; SMN2 (0.45) | ALDH1A1SMN1; SMN2KMT2AGAALMNA | |
| SCHEMBL2554488 | 0.72 | SMN1; SMN2 (0.64) | ALDH1A1SMN1; SMN2KMT2AGAALMNA | |
| SCHEMBL2561393 | 0.72 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2KMT2AGAALMNA | |
| SCHEMBL2563304 | 0.71 | ALOX5 (0.41) | ALDH1A1SMN1; SMN2KMT2AGAALMNA | |
| SCHEMBL5306485 | 0.71 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2KMT2AGAALMNA | |
| SCHEMBL2563603 | 0.70 | SMN1; SMN2 (0.45) | ALDH1A1SMN1; SMN2KMT2AGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011121223-A1 | 6-(ALKYL- OR CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLE DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | WO | disclosed |