Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 3/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16395261 | 0.81 | MAP2K1 (0.57) | MAP2K1ALDH1A1PKMPOLBGAA | |
| SCHEMBL15129410 | 0.80 | KDM4E (0.48) | HSD17B10MAPTALDH1A1LMNAGAA | |
| SCHEMBL1919254 | 0.73 | MAPT (0.58) | PLK1MAPT | |
| SCHEMBL14406018 | 0.73 | MAP2K1 (0.68) | MAP2K1 | |
| SCHEMBL6285909 | 0.72 | KDM4E (0.45) | HSD17B10MAPTALDH1A1MKNK1MKNK2 | |
| SCHEMBL24059139 | 0.71 | NSD2 (0.67) | PLK1PDE4BALDH1A1P2RX7TP53 | |
| SCHEMBL2638921 | 0.70 | ADORA2A (0.70) | MAP2K1 | |
| SCHEMBL4766191 | 0.69 | P2RX7 (0.71) | PLK1MAPTALDH1A1LMNAPOLB | |
| SCHEMBL161745 | 0.69 | GAA (0.48) | PLK1MAPTALDH1A1LMNAPOLB | |
| SCHEMBL93650 | 0.69 | GAA (0.48) | PLK1MAPTALDH1A1RIPK1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560976-A1 | FUROPYRIDINE COMPOUNDS AND USES THEREOF | Novartis AG (CH) | 2013-02-27 | — | — | EP | claimed |
| WO-2011131709-A1 | FUROPYRIDINE COMPOUNDS AND USES THEREOF | NOVARTIS AG (CH) | 2011-10-27 | — | — | WO | claimed |