Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 10/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.42 |
| ▸ | FEN1 | P39748 | 2/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | PRKCH | P24723 | 1/20 | 0.38 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17907560 | 0.82 | DHFR (0.56) | DHFR | |
| SCHEMBL30515653 | 0.82 | DHFR (0.56) | DHFR | |
| SCHEMBL14694265 | 0.76 | DHFR (0.58) | DHFR | |
| SCHEMBL2558872 | 0.75 | DHFR (0.60) | DHFR | |
| SCHEMBL265154 | 0.74 | DHFR (0.59) | DHFR | |
| SCHEMBL30560046 | 0.74 | DHFR (0.59) | DHFR | |
| SCHEMBL3125646 | 0.74 | DDB1 (0.46) | GAKDPP4PRKCHPRKCE | |
| SCHEMBL1991950 | 0.73 | PIK3CA (0.50) | ALOX5APFEN1GAKDPP4AOC3 | |
| SCHEMBL29660579 | 0.73 | PIK3CA (0.50) | ALOX5APFEN1GAKDPP4AOC3 | |
| SCHEMBL14320578 | 0.70 | KDM4E (0.42) | ALOX5APFEN1GAKAOC3PRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558474-A1 | 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2013-02-20 | — | — | EP | claimed |
| WO-2011130390-A1 | 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2011-10-20 | — | — | WO | claimed |