Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.48 |
| ▸ | NOS1 | P29475 | 2/20 | 0.48 |
| ▸ | NOS2 | P35228 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.31 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.31 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20207667 | 0.85 | NOS3 (0.52) | NOS3NOS1NOS2CYP1A2POLB | |
| SCHEMBL218290 | 0.82 | NOS3 (0.61) | NOS3NOS1NOS2CYP1A2POLB | |
| SCHEMBL11563922 | 0.80 | NOS3 (0.59) | NOS3NOS1NOS2CYP1A2POLB | |
| SCHEMBL17000195 | 0.77 | POLB (0.44) | NOS3NOS1NOS2CYP1A2POLB | |
| SCHEMBL16976310 | 0.76 | NOS3 (0.55) | NOS3NOS1NOS2CYP1A2POLB | |
| Dimethylamine SCHEMBL7744073 | 0.76 | NOS3 (0.55) | NOS3NOS1NOS2CYP1A2POLB | |
| SCHEMBL26192789 | 0.76 | NOS3 (0.50) | NOS3NOS1NOS2CYP1A2POLB | |
| SCHEMBL23986930 | 0.74 | NOS3 (0.41) | NOS3NOS1NOS2CYP1A2POLB | |
| SCHEMBL17778607 | 0.73 | NOS3 (0.52) | NOS3NOS1NOS2AAK1LOXL2 | |
| SCHEMBL14470239 | 0.72 | NOS3 (0.55) | NOS3NOS1NOS2CYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091554-A1 | NOVEL HETEROARYL-UREA COMPOUNDS AS KV7.2 INHIBITORS | ICAGEN, LLC (US) | 2023-05-25 | — | — | WO | disclosed |