SCHEMBL256396

SCHEMBL256396

C#Cc1cccc(Nc2ncnc3cc(O)c(O)cc23)c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 17/20 0.69
GAK O14976 3/20 0.69
FBP1 P09467 2/20 0.69
ALDH1A1 P00352 1/20 0.69
MAPT P10636 1/20 0.69
RIPK2 O43353 2/20 0.64
BUB1 O43683 2/20 0.64
STK10 O94804 2/20 0.64
MAP3K1 Q13233 2/20 0.64
PIP4K2C Q8TBX8 2/20 0.64
SLK Q9H2G2 2/20 0.64
CARS1 P49589 1/20 0.64
ERBB2 P04626 4/20 0.62
AURKA O14965 2/20 0.62
ERBB4 Q15303 2/20 0.62
PLK4 O00444 1/20 0.62
CIT O14578 1/20 0.62
EPHB6 O15197 1/20 0.62
SLC22A1 O15245 1/20 0.62
DAPK3 O43293 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL3873473 0.99 EGFR (0.67) EGFRGAKFBP1ALDH1A1MAPT
SCHEMBL2607974 0.90 EGFR (0.67) EGFRGAKFBP1ALDH1A1MAPT
SCHEMBL13285584 0.87 EGFR (0.83) EGFRGAKFBP1ALDH1A1MAPT
SCHEMBL644810 0.87 EGFR (0.83) EGFRGAKFBP1ALDH1A1MAPT
Hydrochloric Acid SCHEMBL28286584 0.86 EGFR (0.82) EGFRGAKFBP1ALDH1A1MAPT
SCHEMBL642044 0.86 EGFR (0.69) EGFRGAKFBP1ALDH1A1MAPT
SCHEMBL28814010 0.85 EGFR (0.58) EGFRGAKFBP1ALDH1A1MAPT
SCHEMBL8684181 0.85 EGFR (0.77) EGFRGAKFBP1ALDH1A1MAPT
SCHEMBL8684647 0.85 EGFR (0.77) EGFRGAKFBP1ALDH1A1MAPT
SCHEMBL4356364 0.85 EGFR (0.69) EGFRGAKFBP1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220162171-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF GASTROINTESTINAL POLYPS Cellix Bio Provate Limited (IN) 2022-05-26 US disclosed
US-11225464-B2 Compositions and methods for the treatment of gastrointestinal polyps CELLIX BIO PRIVATE LIMITED (IN) 2022-01-18 US disclosed
US-20200190040-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF GASTROINTESTINAL POLYPS CELLIX BIO PRIVATE LIMITED (IN) 2020-06-18 US disclosed
WO-2018087605-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF GASTROINTESTINAL POLYPS CELLIX BIO PRIVATE LIMITED (IN) 2018-05-17 WO disclosed
US-20180050993-A1 NOVEL FLUORINATED DERIVATIVES AS EGFR INHIBITORS USEFUL FOR TREATING CANCERS TRILLIUM THERAPEUTICS INC. (CA) 2018-02-22 US disclosed
US-20180050993-A1 NOVEL FLUORINATED DERIVATIVES AS EGFR INHIBITORS USEFUL FOR TREATING CANCERS TRILLIUM THERAPEUTICS INC. (CA) 2018-02-22 US disclosed
US-20180050993-A1 NOVEL FLUORINATED DERIVATIVES AS EGFR INHIBITORS USEFUL FOR TREATING CANCERS TRILLIUM THERAPEUTICS INC. (CA) 2018-02-22 US disclosed
EP-3012251-B1 PROCESS FOR THE PREPARATION OF 6,7-DIALKOXY QUINAZOLINE DERIVATIVES NATCO PHARMA LTD (IN) 2017-08-30 EP disclosed
EP-3015460-B1 PROCESS FOR THE PREPARATION OF ERLOTINIB CERBIOS-PHARMA S A (CH) 2017-05-17 EP disclosed
US-20170079983-A1 6,7-DIALKOXY QUINAZOLINE DERIVATIVES AND METHODS OF TREATING DRUG RESISTANT AND OTHER TUMORS ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI 2017-03-23 US disclosed
US-20090306377-A1 NOVEL PROCESS FOR THE PREPARTION OF ERLOTINIB NATCO PHARMA LIMITED (IN) 2009-12-10 US disclosed
US-20090306377-A1 NOVEL PROCESS FOR THE PREPARTION OF ERLOTINIB NATCO PHARMA LIMITED (IN) 2009-12-10 US disclosed
WO-2008102369-A1 NOVEL POLYMORPHS OF ERLOTINIB HYDROCHLORIDE AND METHOD OF PREPARATION NATCO PHARMA LIMITED (IN) 2008-08-28 WO disclosed
US-20080166358-A1 QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT CONCERT PHARMACEUTICALS INC. (US) 2008-07-10 US disclosed
US-20080166358-A1 QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT CONCERT PHARMACEUTICALS INC. (US) 2008-07-10 US disclosed
US-20080166358-A1 QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT CONCERT PHARMACEUTICALS INC. (US) 2008-07-10 US disclosed
WO-2008076949-A2 QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT CONCERT PHARMACEUTICALS INC. (US) 2008-06-26 WO disclosed
WO-2008076949-A2 QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT CONCERT PHARMACEUTICALS INC. (US) 2008-06-26 WO disclosed
WO-2007060691-A2 A NOVEL PROCESS FOR THE PREPARATION OF ERLOTINIB NATCO PHARMA LIMITED (IN) 2007-05-31 WO disclosed
WO-2007060691-A2 A NOVEL PROCESS FOR THE PREPARATION OF ERLOTINIB NATCO PHARMA LIMITED (IN) 2007-05-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180050993-A1 NOVEL FLUORINATED DERIVATIVES AS EGFR INHIBITORS USEFUL FOR TREATING CANCERS EGFR, ERBB2, ERBB4 EGFR 1/4885GAK 900/4885FBP1 213/4885
US-11225464-B2 Compositions and methods for the treatment of gastrointestinal polyps APC, LPXN, SCNN1G EGFR 2217/4885GAK 2650/4885FBP1 1846/4885
US-20090306377-A1 NOVEL PROCESS FOR THE PREPARTION OF ERLOTINIB ERBB4, ABL1, KRAS EGFR 4/4885GAK 889/4885FBP1 2558/4885
US-20200190040-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF GASTROINTESTINAL POLYPS APC, LPXN, SCNN1G EGFR 2217/4885GAK 2650/4885FBP1 1846/4885
US-20220162171-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF GASTROINTESTINAL POLYPS APC, LPXN, SCNN1G EGFR 2217/4885GAK 2650/4885FBP1 1846/4885
US-20080166358-A1 QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT ABL1, FLT3, GRK5 EGFR 19/4885GAK 892/4885FBP1 3745/4885
US-20170079983-A1 6,7-DIALKOXY QUINAZOLINE DERIVATIVES AND METHODS OF TREATING DRUG RESISTANT AND OTHER TUMORS ERBB2, EGFR, STK17A EGFR 2/4885GAK 274/4885FBP1 1015/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.