Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.69 |
| ▸ | GAK | O14976 | 3/20 | 0.69 |
| ▸ | FBP1 | P09467 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.64 |
| ▸ | BUB1 | O43683 | 2/20 | 0.64 |
| ▸ | STK10 | O94804 | 2/20 | 0.64 |
| ▸ | MAP3K1 | Q13233 | 2/20 | 0.64 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.64 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.64 |
| ▸ | CARS1 | P49589 | 1/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.62 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.62 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.62 |
| ▸ | AURKA | O14965 | 2/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | CIT | O14578 | 1/20 | 0.62 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.62 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28407487 | 1.00 | EGFR (0.69) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL1766075 | 0.90 | EGFR (0.64) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL29614991 | 0.85 | EGFR (0.58) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL1766082 | 0.85 | EGFR (0.58) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL868020 | 0.85 | EGFR (0.68) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL2607975 | 0.85 | EGFR (0.72) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL256396 | 0.85 | EGFR (0.69) | EGFRGAKFBP1ALDH1A1MAPT | |
| SCHEMBL4356364 | 0.85 | EGFR (0.69) | EGFRGAKFBP1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7665701 | 0.84 | EGFR (0.67) | EGFRGAKFBP1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL3873473 | 0.84 | EGFR (0.67) | EGFRGAKFBP1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111763214-B | Preparation method of icotinib | 苏州富士莱医药股份有限公司 | 2022-03-15 | — | — | CN | claimed |
| WO-2022032943-A1 | PREPARATION METHOD FOR ICOTINIB | 苏州富士莱医药股份有限公司 | 2022-02-17 | — | — | WO | claimed |
| CN-111763214-B | Preparation method of icotinib | 苏州富士莱医药股份有限公司 | 2022-03-15 | — | — | CN | disclosed |
| CN-111763214-B | Preparation method of icotinib | 苏州富士莱医药股份有限公司 | 2022-03-15 | — | — | CN | disclosed |
| WO-2022032943-A1 | PREPARATION METHOD FOR ICOTINIB | 苏州富士莱医药股份有限公司 | 2022-02-17 | — | — | WO | disclosed |