Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15719819 | 0.84 | TSHR (0.37) | CYP2C19TSHRMMP2ANPEPBRD4 | |
| SCHEMBL15718956 | 0.82 | BRD4 (0.34) | CYP2C19TSHRMMP2ANPEPBRD4 | |
| SCHEMBL15719829 | 0.82 | MMP2 (0.33) | CYP2C19TSHRMMP2ANPEPBRD4 | |
| SCHEMBL31238977 | 0.78 | CHRM2 (0.37) | CYP2C19TSHR | |
| SCHEMBL2563380 | 0.78 | CHRM2 (0.37) | CYP2C19TSHR | |
| SCHEMBL31234227 | 0.78 | CHRM2 (0.37) | CYP2C19TSHR | |
| SCHEMBL3322134 | 0.78 | CHRM2 (0.37) | CYP2C19TSHR | |
| SCHEMBL2563379 | 0.78 | CHRM2 (0.37) | CYP2C19TSHR | |
| SCHEMBL21360153 | 0.78 | — | — | |
| SCHEMBL5065905 | 0.78 | ATM (0.31) | CYP2C19GBA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069354-B1 | Aza-benzofuranyl compounds and methods of use | GENENTECH INC (US) | 2011-11-02 | — | — | EP | disclosed |
| EP-2069354-A1 | AZA-BENZOFURANYL COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008024725-A1 | AZA-BENZOFURANYL COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2008-02-28 | — | — | WO | disclosed |