Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2564045 | 0.82 | CYP2C19 (0.35) | MMP2ANPEPTSHRBRD4ALDH1A1 | |
| SCHEMBL15719692 | 0.81 | CFD (0.33) | MMP2ANPEPTSHRBRD4 | |
| SCHEMBL15719819 | 0.81 | TSHR (0.37) | MMP2ANPEPTSHRBRD4ALDH1A1 | |
| SCHEMBL15718956 | 0.76 | BRD4 (0.34) | MMP2ANPEPTSHRBRD4ALDH1A1 | |
| SCHEMBL18093995 | 0.74 | NPC1 (0.44) | — | |
| SCHEMBL15719780 | 0.72 | TSHR (0.36) | MMP2ANPEPTSHRBRD4CYP2C19 | |
| SCHEMBL21360153 | 0.72 | — | — | |
| SCHEMBL18614432 | 0.71 | AR (0.36) | ALDH1A1 | |
| SCHEMBL15721076 | 0.71 | BRD4 (0.33) | MMP2ANPEPTSHRBRD4 | |
| SCHEMBL20488623 | 0.70 | ACE (0.35) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925741-A1 | PYRROLIDINE GPR40 MODULATORS | Bristol-Myers Squibb Company (US) | 2015-10-07 | — | — | EP | disclosed |
| WO-2014078609-A1 | PYRROLIDINE GPR40 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-05-22 | — | — | WO | disclosed |