Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PRKX | P51817 | 1/20 | 0.47 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.47 |
| ▸ | PDE1A | P54750 | 1/20 | 0.47 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.47 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | XDH | P47989 | 2/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2559812 | 0.80 | GUSB (0.55) | GUSBALDH1A1PDE5AKDM4EUSP2 | |
| SCHEMBL2566798 | 0.78 | GUSB (0.51) | GUSBALDH1A1PDE5AKDM4EUSP2 | |
| SCHEMBL16198788 | 0.78 | GUSB (0.53) | GUSBALDH1A1PDE5AKDM4EUSP2 | |
| SCHEMBL7937930 | 0.76 | PDE5A (0.55) | GUSBSMN1; SMN2ALDH1A1PDE5AKDM4E | |
| SCHEMBL4822785 | 0.75 | GSK3B (0.84) | SMN1; SMN2ALDH1A1GSK3BKDM4EHPGD | |
| SCHEMBL2565233 | 0.75 | GUSB (0.62) | GUSBALDH1A1PDE5AKDM4EHPGD | |
| SCHEMBL4196255 | 0.75 | MEN1 (0.70) | GUSBPDE5AKDM4EPOLB | |
| SCHEMBL29732712 | 0.75 | MEN1 (0.70) | GUSBPDE5AKDM4EPOLB | |
| SCHEMBL7160589 | 0.74 | GUSB (1.00) | GUSBPDE5AKDM4EHPGDPDE1A | |
| SCHEMBL31238756 | 0.74 | GUSB (1.00) | GUSBPDE5AKDM4EHPGDPDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2383262-B1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | TOPHARMAN SHANGHAI CO LTD (CN) | 2016-07-06 | — | — | EP | disclosed |
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| EP-2383262-A1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | Topharman Shanghai Co., Ltd. (CN) | 2011-11-02 | — | — | EP | disclosed |