Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 6/20 | 0.46 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1352182 | 0.88 | DRD2 (0.51) | DRD2DRD4DRD3SIGMAR1CHRM3 | |
| SCHEMBL691879 | 0.80 | DRD2 (0.48) | AVPR1ADRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL2012961 | 0.78 | CYP2D6 (0.47) | DRD2DRD4DRD3SIGMAR1BCHE | |
| SCHEMBL2017528 | 0.78 | AVPR1A (0.42) | AVPR1ADRD2DRD4ALDH1A1MAPT | |
| SCHEMBL1350975 | 0.77 | HTR3E (0.46) | DRD2DRD4DRD3SIGMAR1CHRM3 | |
| SCHEMBL692590 | 0.76 | CYP2D6 (0.44) | DRD2DRD4DRD3SIGMAR1CHRM3 | |
| SCHEMBL2014482 | 0.76 | CYP2D6 (0.44) | DRD2DRD4DRD3SIGMAR1CHRM3 | |
| SCHEMBL692244 | 0.74 | DRD2 (0.47) | AVPR1ADRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL691313 | 0.74 | DRD2 (0.47) | AVPR1ADRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL2017936 | 0.74 | HTR2C (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560973-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbvie Inc. (US) | 2013-02-27 | — | — | EP | claimed |
| WO-2011133182-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-10-27 | — | — | WO | claimed |