Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.43 |
| ▸ | PTGES | O14684 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18626138 | 1.00 | APP (0.52) | APPFFAR1FFAR4PTGESCYP1A2 | |
| SCHEMBL11232546 | 0.91 | FFAR1 (0.53) | APPFFAR1FFAR4PTGESCYP1A2 | |
| SCHEMBL15266861 | 0.91 | FFAR1 (0.49) | APPFFAR1FFAR4PTGESCYP1A2 | |
| SCHEMBL22622902 | 0.89 | GRM5 (0.44) | APPFFAR1FFAR4PTGESCYP1A2 | |
| SCHEMBL11225320 | 0.89 | CYP1A2 (0.55) | APPFFAR1FFAR4PTGESCYP1A2 | |
| SCHEMBL8752132 | 0.89 | CYP1A2 (0.55) | APPFFAR1FFAR4PTGESCYP1A2 | |
| SCHEMBL20613702 | 0.88 | FFAR1 (0.46) | APPFFAR1FFAR4PTGESCYP1A2 | |
| SCHEMBL2298384 | 0.85 | APP (0.42) | APPFFAR1FFAR4PTGESCYP1A2 | |
| SCHEMBL1200030 | 0.85 | SIGMAR1 (0.45) | APPFFAR1FFAR4PTGESCYP1A2 | |
| SCHEMBL28789381 | 0.85 | HAO1 (0.45) | APPFFAR1FFAR4PTGESCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10927093-B1 | Method for synthesizing 2-benzylidene tetrahydrothiophene derivative | SOOCHOW UNIVERSITY (CN) | 2021-02-23 | — | — | US | claimed |
| US-20210040060-A1 | METHOD FOR SYNTHESIZING 2-BENZYLIDENE TETRAHYDROTHIOPHENE DERIVATIVE | SOOCHOW UNIVERSITY (CN) | 2021-02-11 | — | — | US | claimed |
| US-10927093-B1 | Method for synthesizing 2-benzylidene tetrahydrothiophene derivative | SOOCHOW UNIVERSITY (CN) | 2021-02-23 | — | — | US | disclosed |
| US-20210040060-A1 | METHOD FOR SYNTHESIZING 2-BENZYLIDENE TETRAHYDROTHIOPHENE DERIVATIVE | SOOCHOW UNIVERSITY (CN) | 2021-02-11 | — | — | US | disclosed |
| WO-2019153373-A1 | METHOD FOR SYNTHESIZING 2-BENZYLIDENE TETRAHYDROTHIOPHENE DERIVATIVE | 苏州大学张家港工业技术研究院 | 2019-08-15 | — | — | WO | disclosed |
| CN-108892604-A | A method of preparing halogenated benzo [b] Fluorenone series compound | 江西师范大学 | 2018-11-27 | — | — | CN | disclosed |
| CN-107848976-A | Alkynyl pyridines prolyl hydroxylase inhibitors, its preparation method and medical usage | 江苏恒瑞医药股份有限公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-105130888-A | Pyridylacetylene prolyl hydroxylase inhibitor and preparation method and medical application thereof | UNIV CHINA PHARMA | 2015-12-09 | — | — | CN | disclosed |
| US-8354398-B2 | Substituted isoxazole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-01-15 | — | — | US | disclosed |
| US-20110300165-A1 | SUBSTITUTED ISOXAZOLE COMPOUNDS | The Board of TRustees of the University of Illinoi University of Illinios (US) | 2011-12-08 | — | — | US | disclosed |
| EP-2382212-A1 | SUBSTITUTED OXADIAZOLE DERIVATIVES AS S1P AGONISTS IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES | Bristol-Myers Squibb Company (US) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010085581-A1 | SUBSTITUTED OXADIAZOLE DERIVATIVES AS S1P AGONISTS IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10927093-B1 | Method for synthesizing 2-benzylidene tetrahydrothiophene derivative | CBR3, TST, C5 | APP 1025/4885FFAR1 4299/4885FFAR4 4130/4885 |
| US-20210040060-A1 | METHOD FOR SYNTHESIZING 2-BENZYLIDENE TETRAHYDROTHIOPHENE DERIVATIVE | CBR3, TST, C5 | APP 1025/4885FFAR1 4299/4885FFAR4 4130/4885 |
| US-20110300165-A1 | SUBSTITUTED ISOXAZOLE COMPOUNDS | S1PR4, S1PR3, S1PR1 | APP 3751/4885FFAR1 69/4885FFAR4 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.