SCHEMBL2565515

SCHEMBL2565515

O=c1c(Cc2cccnc2)c[nH]n1-c1ccc(S(=O)(=O)N(CC(O)CO)c2ccccc2)cn1

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
VHL P40337 3/20 0.40
EGLN1 Q9GZT9 1/20 0.37
P4HTM Q9NXG6 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
KMT2A Q03164 4/20 0.35
BACE1 P56817 4/20 0.35
LMNA P02545 2/20 0.35
MEN1 O00255 2/20 0.35
MAPT P10636 2/20 0.35
KDM4E B2RXH2 1/20 0.35
GAA P10253 1/20 0.35
HPGD P15428 1/20 0.35
HTT P42858 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
ADAMTS4 O75173 1/20 0.35
TP53 P04637 1/20 0.34
POLB P06746 1/20 0.34
ALOX15 P16050 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL15258734 0.99 VHL (0.40) VHLEGLN1P4HTMSMN1; SMN2L3MBTL1
SCHEMBL2569670 0.94 L3MBTL1 (0.38) EGLN1SMN1; SMN2L3MBTL1KMT2ABACE1
SCHEMBL15258861 0.87 SMN1; SMN2 (0.46) VHLP4HTMSMN1; SMN2L3MBTL1KMT2A
SCHEMBL2569769 0.80 EGLN1 (0.36) VHLEGLN1P4HTMSMN1; SMN2LMNA
SCHEMBL2571634 0.79 ALDH1A1 (0.51) SMN1; SMN2L3MBTL1KMT2ALMNAMEN1
SCHEMBL2567060 0.79 BACE1 (0.41) EGLN1SMN1; SMN2BACE1LMNAKDM4E
SCHEMBL2565025 0.79 BACE1 (0.41) EGLN1SMN1; SMN2BACE1LMNAKDM4E
SCHEMBL15258726 0.79 BACE1 (0.41) EGLN1SMN1; SMN2BACE1LMNAKDM4E
SCHEMBL2569164 0.76 P4HTM (0.43) VHLEGLN1P4HTMKMT2ALMNA
SCHEMBL2571477 0.76 KDM4E (0.41) EGLN1SMN1; SMN2L3MBTL1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2382205-B1 DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF AS HIF ACTIVATORS SANOFI SA (FR) 2014-04-23 EP claimed
EP-2382205-A2 DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF AS HIF ACTIVATORS SANOFI (FR) 2011-11-02 EP claimed
WO-2010076524-A2 DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF AS HIF ACTIVATORS SANOFI-AVENTIS (FR) 2010-07-08 WO claimed
EP-2382205-B1 DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF AS HIF ACTIVATORS SANOFI SA (FR) 2014-04-23 EP disclosed