Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.64 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | SNCA | P37840 | 1/20 | 0.56 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.54 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CKS1B | P61024 | 1/20 | 0.52 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.50 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL784141 | 0.89 | KEAP1 (0.66) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL5609957 | 0.85 | KEAP1 (0.59) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL5015931 | 0.85 | KEAP1 (0.68) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL29118864 | 0.85 | KEAP1 (0.65) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL30676966 | 0.85 | KEAP1 (0.65) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL1990223 | 0.83 | KEAP1 (0.73) | KEAP1KMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL7856929 | 0.81 | KEAP1 (0.63) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL15314389 | 0.81 | KMT2A (0.65) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL5330736 | 0.81 | ALDH1A1 (0.64) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 | |
| SCHEMBL11655582 | 0.80 | SNCA (0.60) | KEAP1NFE2L2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382215-A1 | DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010076525-A1 | DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-07-08 | — | — | WO | disclosed |