Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cholesterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OSBP | P22059 | 4/20 | 0.91 |
| ▸ | RORC | P51449 | 4/20 | 0.91 |
| ▸ | OSBP2 | Q969R2 | 2/20 | 0.91 |
| ▸ | USP2 | O75604 | 1/20 | 0.91 |
| ▸ | LMNA | P02545 | 1/20 | 0.91 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.91 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.91 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.78 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.78 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.78 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.78 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.74 |
| ▸ | CRYAB | P02511 | 1/20 | 0.74 |
| ▸ | HMGCR | P04035 | 1/20 | 0.74 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.74 |
| ▸ | ITGAV | P06756 | 1/20 | 0.74 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.74 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.73 |
| ▸ | POLA1 | P09884 | 1/20 | 0.72 |
| ▸ | DHCR24 | Q15392 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cholesterol SCHEMBL29491181 | 1.00 | OSBP (0.91) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27420666 | 1.00 | OSBP (0.91) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL28072252 | 0.97 | OSBP (0.86) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL29502101 | 0.97 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL28352779 | 0.97 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL1369602 | 0.97 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27668883 | 0.97 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL30101141 | 0.96 | OSBP (0.91) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL31090041 | 0.96 | OSBP (0.91) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27608874 | 0.96 | OSBP (0.91) | OSBPRORCOSBP2USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1031 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025133105-A1 | COMPOSITIONS AND METHODS | BIONTECH DELIVERY TECHNOLOGIES GMBH (DE) | 2025-06-26 | — | — | WO | claimed |
| CN-119997933-A | Oral pharmaceutical composition containing taxane and preparation method thereof | 韩国科学技术研究院 | 2025-05-13 | — | — | CN | claimed |
| CN-119522092-A | Multivalent molecule-based lipid nanoparticles for nucleic acid delivery | 比奥-特里普公司 | 2025-02-25 | — | — | CN | claimed |
| CN-119138513-A | Application of camellia seed oil in preparation of beef cattle quality improving products | 吉林大学 | 2024-12-17 | — | — | CN | claimed |
| CN-118852308-B | Red light-emitting gel factor, fibrous gel soft material, and preparation methods and application thereof | 德州学院 | 2024-12-10 | — | — | CN | claimed |
| CN-119044072-A | Liquid crystal sensor for detecting formaldehyde gas and preparation method thereof | 江南大学 | 2024-11-29 | — | — | CN | claimed |
| CN-118852308-A | Red light-emitting gel factor, fibrous gel soft material, and preparation methods and application thereof | 德州学院 | 2024-10-29 | — | — | CN | claimed |
| CN-114225964-B | Immobilized N-hydroxyphthalimide resin, preparation method and application thereof, and preparation method of 7-ketocholesterol acetate | 厦门金达威维生素有限公司 | 2024-10-18 | — | — | CN | claimed |
| CN-118105331-A | Soluble microneedle based on inflammation site targeting nanoparticle and preparation method and application thereof | 中国药科大学 | 2024-05-31 | — | — | CN | claimed |
| CN-117597118-A | Pharmaceutical composition for preventing or treating viral infection comprising as active ingredient a crude drug | QVET公司 | 2024-02-23 | — | — | CN | claimed |
| WO-1990010437-A1 | PARTIALLY FUSED PEPTIDE PELLET | ENDOCON, INC. (US) | 1990-09-20 | — | — | WO | claimed |
| EP-0357644-A1 | FLASH FLOW FUSED MEDICINAL IMPLANTS. | ENDOCON INC (US) | 1990-03-14 | — | — | EP | claimed |
| US-4892734-A | Dispensing paste for forming medicinal pellets | ENDOCON, INC. (US) | 1990-01-09 | — | — | US | claimed |
| CN-1037456-A | The mobile fast medicinal implants that merges | ENDOCON INC (US) | 1989-11-29 | — | — | CN | claimed |
| CN-1035145-A | FLUID CRYSTAL PRINTING WITH POLYURETHANL METHOD | WUHAN INST OF TEXTILE SCIENCE (CN) | 1989-08-30 | — | — | CN | claimed |
| WO-1988007816-A1 | FLASH FLOW FUSED MEDICINAL IMPLANTS | ENDOCON, INC. (US) | 1988-10-20 | — | — | WO | claimed |
| US-4748024-A | Flash flow fused medicinal implants | ENDOCON, INC. (US) | 1988-05-31 | — | — | US | claimed |
| US-4684479-A | Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures | CAVITATION-CONTROL TECHNOLOGY, INC. | 1987-08-04 | — | — | US | claimed |
| US-4305880-A | VITAMIN D | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1981-12-15 | — | — | US | claimed |
| US-4115313-A | FATTY ACIDS, PHOSPHOLIPIDS, STEROIDS | LYON IRVING | 1978-09-19 | — | — | US | claimed |