Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cholesterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OSBP | P22059 | 4/20 | 0.86 |
| ▸ | RORC | P51449 | 4/20 | 0.86 |
| ▸ | OSBP2 | Q969R2 | 2/20 | 0.86 |
| ▸ | USP2 | O75604 | 1/20 | 0.86 |
| ▸ | LMNA | P02545 | 1/20 | 0.86 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.86 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.86 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.80 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.80 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.76 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.74 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.70 |
| ▸ | CRYAB | P02511 | 1/20 | 0.70 |
| ▸ | HMGCR | P04035 | 1/20 | 0.70 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.70 |
| ▸ | ITGAV | P06756 | 1/20 | 0.70 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.70 |
| ▸ | DHCR24 | Q15392 | 2/20 | 0.70 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.69 |
| ▸ | POLA1 | P09884 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cholesterol SCHEMBL29491181 | 0.97 | OSBP (0.91) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL25657 | 0.97 | OSBP (0.91) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27420666 | 0.97 | OSBP (0.91) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL21681224 | 0.95 | OSBP (0.94) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL454868 | 0.95 | OSBP (0.94) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL454869 | 0.95 | OSBP (0.94) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL29502101 | 0.95 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL28352779 | 0.95 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27668883 | 0.95 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL1369602 | 0.95 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108026131-B | Polymer-cyclodextrin-lipid conjugates | 吴念 | 2021-12-10 | — | — | CN | disclosed |
| CN-113274506-A | Drug delivery technology of polymer-carbohydrate conjugates | 念·吴 | 2021-08-20 | — | — | CN | disclosed |
| CN-108026131-A | POLYMER-CYCLODEXTRIN-LIPID CONJUGATES | 吴念 | 2018-05-11 | — | — | CN | disclosed |
| CN-105792850-A | Drug delivery technology of polymer-carbohydrate conjugates | 念·吴 | 2016-07-20 | — | — | CN | disclosed |