Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cholesterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OSBP | P22059 | 5/20 | 0.93 |
| ▸ | RORC | P51449 | 3/20 | 0.93 |
| ▸ | OSBP2 | Q969R2 | 2/20 | 0.93 |
| ▸ | USP2 | O75604 | 1/20 | 0.93 |
| ▸ | LMNA | P02545 | 1/20 | 0.93 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.93 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.93 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.79 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.79 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.79 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.79 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.75 |
| ▸ | CRYAB | P02511 | 1/20 | 0.75 |
| ▸ | HMGCR | P04035 | 1/20 | 0.75 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.75 |
| ▸ | ITGAV | P06756 | 1/20 | 0.75 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.75 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.74 |
| ▸ | POLA1 | P09884 | 1/20 | 0.73 |
| ▸ | DHCR24 | Q15392 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cholesterol SCHEMBL27668883 | 1.00 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL29502101 | 1.00 | OSBP (0.93) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27608874 | 0.99 | OSBP (0.91) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL31090041 | 0.97 | OSBP (0.91) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL25657 | 0.97 | OSBP (0.91) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27420666 | 0.97 | OSBP (0.91) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL30101141 | 0.97 | OSBP (0.91) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL29491181 | 0.97 | OSBP (0.91) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL2460866 | 0.97 | OSBP (0.98) | OSBPRORCOSBP2USP2LMNA | |
| Cholesterol SCHEMBL27893800 | 0.97 | OSBP (0.98) | OSBPRORCOSBP2USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 182 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265123-A1 | PEPTIDES AND FORMULATIONS FOR CANCER TREATMENT | PEPTINOVO BIOPHARMA INC. | 2023-08-24 | — | — | US | claimed |
| EP-4196166-A2 | PEPTIDES AND FORMULATIONS FOR CANCER TREATMENT | Peptinovo Biopharma Inc. (US) | 2023-06-21 | — | — | EP | claimed |
| CN-111568631-B | Cooling paste with temperature indication function and preparation method thereof | 武汉中科先进材料科技有限公司 | 2022-08-05 | — | — | CN | claimed |
| CN-108350036-B | Formulations for improving the efficacy of hydrophobic drugs | 佩蒂诺沃生物制药有限责任公司 | 2022-04-08 | — | — | CN | claimed |
| CN-122029108-A | Temporary containment barrier and related methods | 纽森斯IP公司 | 2026-05-12 | — | — | CN | disclosed |
| CN-120040306-A | Diamines | 日产化学株式会社 | 2025-05-27 | — | — | CN | disclosed |
| CN-120004765-A | Liquid crystal aligning agent, liquid crystal alignment film, liquid crystal display element, and diamine | 日产化学株式会社 | 2025-05-16 | — | — | CN | disclosed |
| CN-113711117-B | Liquid crystal aligning agent, liquid crystal alignment film, liquid crystal display element, and diamine | 日产化学株式会社 | 2025-02-21 | — | — | CN | disclosed |
| CN-115136068-B | Liquid crystal aligning agent, liquid crystal alignment film, liquid crystal display element, and diamine | 日产化学株式会社 | 2025-02-14 | — | — | CN | disclosed |
| CN-119236187-A | Polymer encapsulated drug particles | 吉益医疗公司 | 2025-01-03 | — | — | CN | disclosed |
| CN-113396359-B | Liquid crystal aligning agent, liquid crystal alignment film, and liquid crystal display element using same | 日产化学株式会社 | 2024-12-17 | — | — | CN | disclosed |
| CN-115461096-B | Polymer encapsulated drug particles | 吉益医疗公司 | 2024-09-13 | — | — | CN | disclosed |
| US-20020132007-A1 | Sustainded-release composition including amorphous polymer | UNIVERSITY TECHNOLOGY CORPORATION | 2002-09-19 | — | — | US | disclosed |
| US-20020032166-A1 | Biocompatible cationic detergents and uses therefor | UNIVERSITY TECHNOLOGY CORPORATION | 2002-03-14 | — | — | US | disclosed |
| EP-1073419-A2 | SUSTAINED-RELEASE COMPOSITION INCLUDING AMORPHOUS POLYMER | University Technology Corporation (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999047543-A2 | SUSTAINED-RELEASE COMPOSITION INCLUDING AMORPHOUS POLYMER | UNIVERSITY TECHNOLOGY CORPORATION (US) | 1999-09-23 | — | — | WO | disclosed |
| WO-1998010649-A9 | BIOCOMPATIBLE CATIONIC DETERGENTS AND USES THEREFOR | — | 1998-05-22 | — | — | WO | disclosed |
| WO-1998010649-A1 | BIOCOMPATIBLE CATIONIC DETERGENTS AND USES THEREFOR | UNIVERSITY TECHNOLOGY CORPORATION (US) | 1998-03-19 | — | — | WO | disclosed |
| US-4035060-A | Electro-optic device | DAINIPPON PRINTING CO., LTD (JA) | 1977-07-12 | — | — | US | disclosed |
| US-3944330-A | Electro-optic device | DAINIPPON PRINTING CO., LTD. (JA) | 1976-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265123-A1 | PEPTIDES AND FORMULATIONS FOR CANCER TREATMENT | PHOSPHO1, NGLY1, ANXA11 | OSBP 301/4885RORC 4350/4885OSBP2 218/4885 |
| US-20020132007-A1 | Sustainded-release composition including amorphous polymer | CHERP, ATP2A1, ATP2A3 | OSBP 1596/4885RORC 3737/4885OSBP2 799/4885 |
| US-20020032166-A1 | Biocompatible cationic detergents and uses therefor | HASPIN, WASF2, DSC1 | OSBP 590/4885RORC 3961/4885OSBP2 808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.