Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Cinoxate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | F3 | P13726 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cinoxate SCHEMBL15558 | 0.87 | LMNA (0.67) | LMNATDP1SMN1; SMN2MEN1KMT2A | |
| Cinoxate SCHEMBL318972 | 0.87 | LMNA (0.67) | LMNATDP1SMN1; SMN2MEN1KMT2A | |
| Cinoxate SCHEMBL6851231 | 0.87 | LMNA (0.67) | LMNATDP1SMN1; SMN2MEN1KMT2A | |
| Cinoxate SCHEMBL1907002 | 0.87 | LMNA (0.67) | LMNATDP1SMN1; SMN2MEN1KMT2A | |
| 4-Methoxycinnamic Acid SCHEMBL28574898 | 0.82 | THRB (0.59) | LMNATDP1SMN1; SMN2MEN1KMT2A | |
| 4-Methoxycinnamic Acid SCHEMBL28574899 | 0.82 | THRB (0.59) | LMNATDP1SMN1; SMN2MEN1KMT2A | |
| Cinoxate SCHEMBL10337529 | 0.82 | THRB (0.59) | LMNATDP1SMN1; SMN2MEN1KMT2A | |
| Cinoxate SCHEMBL30139914 | 0.78 | LMNA (0.53) | LMNATDP1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL28533768 | 0.77 | MAOB (0.56) | LMNATDP1SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL28533767 | 0.77 | MAOB (0.56) | LMNATDP1SMN1; SMN2KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9724544-B2 | Vitamin D promoting sunscreen | Armstrong, Ernest T. (US) | 2017-08-08 | — | — | US | disclosed |
| EP-2384193-A2 | VITAMIN D PROMOTING SUNSCREEN | Armstrong, Ernest T. (US) | 2011-11-09 | — | — | EP | disclosed |
| US-20110268678-A1 | VITAMIN D FORMING SUNSCREEN | ARMSTRONG ERNEST T | 2011-11-03 | — | — | US | disclosed |
| WO-2010076731-A2 | VITAMIN D PROMOTING SUNSCREEN | ARMSTRONG ERNEST T (US) | 2010-07-08 | — | — | WO | disclosed |