Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.47 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25498357 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2L3MBTL1L3MBTL3HPGDPRKAA2 | |
| SCHEMBL12286062 | 0.82 | TDP1 (0.60) | SMN1; SMN2SCN7AKCNH2SCN9AL3MBTL1 | |
| SCHEMBL20750490 | 0.79 | CCNC (0.47) | SMN1; SMN2SCN7AKCNH2SCN9AL3MBTL1 | |
| SCHEMBL20803928 | 0.78 | SCN9A (0.48) | SMN1; SMN2SCN7AKCNH2SCN9AL3MBTL1 | |
| SCHEMBL30863972 | 0.76 | GRM5 (0.55) | SMN1; SMN2L3MBTL1HPGDSIGMAR1MKNK1 | |
| SCHEMBL4935859 | 0.76 | MAPT (0.51) | SMN1; SMN2KCNH2HRH3ALDH1A1MAPT | |
| SCHEMBL1430481 | 0.76 | GRM5 (0.55) | SMN1; SMN2L3MBTL1HPGDSIGMAR1MKNK1 | |
| SCHEMBL24967911 | 0.75 | SCN9A (0.60) | SCN7AKCNH2SCN9AL3MBTL1 | |
| SCHEMBL26421763 | 0.75 | SIGMAR1 (0.50) | SMN1; SMN2HPGDSIGMAR1MKNK1MKNK2 | |
| SCHEMBL8253628 | 0.75 | SIGMAR1 (0.57) | SMN1; SMN2KCNH2L3MBTL1HPGDSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023086399-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |