Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.48 |
| ▸ | SCN7A | Q01118 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 2/20 | 0.40 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12186155 | 0.87 | KMT2A (0.54) | TDP1SMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL10329767 | 0.87 | SMN1; SMN2 (0.58) | KCNH2TDP1SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL26772953 | 0.85 | HRH3 (0.53) | TDP1SMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL24370438 | 0.84 | TDP1 (0.48) | TDP1SMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL19473337 | 0.83 | SMN1; SMN2 (0.65) | TDP1SMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL19105545 | 0.81 | SIGMAR1 (0.42) | SCN9ASCN7AKCNH2SCN10ASCN5A | |
| SCHEMBL12286062 | 0.81 | TDP1 (0.60) | SCN9ASCN7AKCNH2TDP1SMN1; SMN2 | |
| SCHEMBL13466364 | 0.78 | PLA2G1B (0.45) | SCN9ASCN10ATDP1SMN1; SMN2MEN1 | |
| SCHEMBL25658374 | 0.78 | SMN1; SMN2 (0.55) | SCN9ASCN7AKCNH2TDP1SMN1; SMN2 | |
| SCHEMBL20750490 | 0.78 | CCNC (0.47) | SCN9ASCN7AKCNH2SCN10ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10633350-B2 | Diphenyl derivatives and uses thereof | NOVARTIS AG (CH) | 2020-04-28 | — | — | US | disclosed |
| US-20190077773-A1 | DIPHENYL DERIVATIVES AND USES THEREOF | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2019-03-14 | — | — | US | disclosed |
| US-20160118591-A1 | ORGANIC ELECTROLUMINESCENT DEVICE | HODOGAYA CHEMICAL CO., LTD. (JP) | 2016-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190077773-A1 | DIPHENYL DERIVATIVES AND USES THEREOF | MYOF, NGF, MUSK | SCN9A 2916/4885SCN7A 2909/4885KCNH2 4689/4885 |
| US-10633350-B2 | Diphenyl derivatives and uses thereof | MYOF, NGF, MUSK | SCN9A 2916/4885SCN7A 2909/4885KCNH2 4689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.