⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19692983 | 0.85 | — | — | |
| SCHEMBL25396598 | 0.77 | DUT (0.47) | — | |
| SCHEMBL19709263 | 0.77 | DUT (0.47) | — | |
| SCHEMBL15294572 | 0.77 | DUT (0.47) | — | |
| SCHEMBL24487841 | 0.77 | DUT (0.47) | — | |
| SCHEMBL15283789 | 0.77 | DUT (0.47) | — | |
| SCHEMBL19397186 | 0.77 | DUT (0.47) | — | |
| SCHEMBL19693019 | 0.75 | — | — | |
| SCHEMBL21242188 | 0.72 | — | — | |
| SCHEMBL31160262 | 0.71 | TYMP (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464313-A1 | 5'-CYCLO-PHOSPHONATE MODIFIED NUCLEOTIDES | Arrowhead Pharmaceuticals, Inc. (US) | 2019-04-10 | — | — | EP | disclosed |
| WO-2017214112-A1 | 5'-CYCLO-PHOSPHONATE MODIFIED NUCLEOTIDES | Arrowhead Pharmaceuticals, Inc. (US) | 2017-12-14 | — | — | WO | disclosed |
| WO-2011133868-A2 | CONFORMATIONALLY RESTRICTED DINUCLEOTIDE MONOMERS AND OLIGONUCLEOTIDES | ALNYLAM PHARMACEUTICALS, INC. (US) | 2011-10-27 | — | — | WO | disclosed |