Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.66 |
| ▸ | RAB9A | P51151 | 7/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.66 |
| ▸ | TP53 | P04637 | 5/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.66 |
| ▸ | RELA | Q04206 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.64 |
| ▸ | MEN1 | O00255 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | AR | P10275 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21348648 | 0.89 | RXFP1 (0.65) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL13139983 | 0.88 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL17660209 | 0.87 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL6802217 | 0.82 | NPC1 (0.83) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL2564458 | 0.82 | RAB9A (0.62) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL2564961 | 0.81 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL8363735 | 0.80 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL5400469 | 0.80 | AR (0.89) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL12167724 | 0.80 | AR (0.89) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL5226157 | 0.80 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2TP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382194-A2 | COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE | RESVERLOGIX CORP. (CA) | 2011-11-02 | — | — | EP | disclosed |