Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12669 | 1.00 | HRH3 (0.44) | HRH3SIGMAR1MAOBHRH2HRH1 | |
| SCHEMBL12449703 | 1.00 | HRH3 (0.44) | HRH3SIGMAR1MAOBHRH2HRH1 | |
| SCHEMBL13052 | 0.89 | HRH3 (0.56) | HRH3MAOBHRH2HRH1ALDH1A1 | |
| SCHEMBL12449644 | 0.89 | HRH3 (0.56) | HRH3MAOBHRH2HRH1ALDH1A1 | |
| SCHEMBL12449633 | 0.89 | HRH3 (0.56) | HRH3MAOBHRH2HRH1ALDH1A1 | |
| SCHEMBL12704907 | 0.88 | SIGMAR1 (0.54) | HRH3SIGMAR1MAOBHRH2HRH1 | |
| SCHEMBL12449698 | 0.88 | ALDH1A1 (0.46) | HRH3SIGMAR1ALDH1A1KDM4E | |
| SCHEMBL12449700 | 0.88 | ALDH1A1 (0.46) | HRH3SIGMAR1ALDH1A1KDM4E | |
| SCHEMBL12951 | 0.88 | ALDH1A1 (0.46) | HRH3SIGMAR1ALDH1A1KDM4E | |
| SCHEMBL9374563 | 0.83 | SIGMAR1 (0.46) | HRH3SIGMAR1KDM4ERECQLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3856719-B1 | COMPOUNDS AS NEURONAL HISTAMINE RECEPTOR-3 ANTAGONISTS AND USES THEREOF | XWPHARMA LTD (KY) | 2023-06-07 | — | — | EP | disclosed |