Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | USP2 | O75604 | 3/20 | 0.56 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.56 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.55 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159319 | 1.00 | MEN1 (0.56) | MEN1KMT2ARAB9ANPC1USP2 | |
| SCHEMBL20309510 | 0.90 | MEN1 (0.54) | MEN1KMT2ARAB9ANPC1USP2 | |
| SCHEMBL28550147 | 0.88 | MEN1 (0.55) | MEN1KMT2ARAB9ANPC1USP2 | |
| SCHEMBL3697106 | 0.83 | KMT2A (0.51) | MEN1KMT2ARAB9ANPC1USP2 | |
| SCHEMBL3697104 | 0.83 | KMT2A (0.51) | MEN1KMT2ARAB9ANPC1USP2 | |
| SCHEMBL3621033 | 0.83 | CYP2A6 (0.60) | MEN1KMT2ARAB9ANPC1USP2 | |
| SCHEMBL10489040 | 0.82 | CYP2A6 (0.69) | MEN1KMT2ARAB9ANPC1USP2 | |
| SCHEMBL27854157 | 0.82 | KMT2A (0.50) | MEN1KMT2ARAB9ANPC1USP2 | |
| SCHEMBL12425727 | 0.82 | CYP2A6 (0.55) | MEN1KMT2ARAB9ANPC1USP2 | |
| SCHEMBL3435669 | 0.82 | CYP2A6 (0.55) | MEN1KMT2ARAB9ANPC1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157306-A1 | Substituted Fused Pyrimidinones and Dihydropyrimidinones | BAYER CROPSCIENCE AG (DE) | 2012-06-21 | — | — | US | disclosed |
| WO-2012028578-A1 | SUBSTITUTED FUSED PYRIMIDINONES AND DIHYDROPYRIMIDINONES | BAYER CROPSCIENCE AG (DE) | 2012-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157306-A1 | Substituted Fused Pyrimidinones and Dihydropyrimidinones | DHPS, FDPS, DPYD | MEN1 3414/4885KMT2A 3719/4885RAB9A 783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.