Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | DBH | P09172 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1608499 | 0.89 | HDAC6 (0.46) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL1607624 | 0.82 | HDAC6 (0.45) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL24071548 | 0.80 | DBH (0.46) | DBH | |
| SCHEMBL1608413 | 0.78 | HDAC6 (0.47) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL25667171 | 0.77 | HDAC6 (0.42) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL1607617 | 0.76 | HDAC6 (0.61) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL1608508 | 0.74 | HDAC6 (0.52) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL1607654 | 0.73 | HDAC6 (0.49) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL1608632 | 0.73 | HDAC6 (0.47) | HDAC6HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL1608418 | 0.72 | HDAC6 (0.52) | HDAC6HDAC1HDAC8HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192684-A1 | SUBSTITUTED INDOLES WITH INHIBITORY ACTIVITY | UNIV OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER HIGHER EDUCATION (US) | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192684-A1 | SUBSTITUTED INDOLES WITH INHIBITORY ACTIVITY | IDO1, IDO2, INMT | HDAC6 1523/4885HDAC1 1028/4885HDAC8 2097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.