Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2017678 | 1.00 | SOS1 (0.41) | SOS1DRD2DRD4HTR1AADRA2A | |
| SCHEMBL2018737 | 0.90 | SOS1 (0.41) | SOS1DRD2DRD4HTR1AADRA2A | |
| SCHEMBL696852 | 0.81 | SOS1 (0.41) | SOS1DRD2DRD4HTR1AADRA2A | |
| SCHEMBL2016220 | 0.81 | SOS1 (0.41) | SOS1DRD2DRD4HTR1AADRA2A | |
| SCHEMBL2012961 | 0.78 | CYP2D6 (0.47) | DRD2DRD4HTR1AADRA1DADRA1A | |
| SCHEMBL2017778 | 0.76 | HTR2C (0.58) | HTR2AHTR2CHTR2B | |
| SCHEMBL692644 | 0.76 | HTR2C (0.58) | HTR2AHTR2CHTR2B | |
| SCHEMBL2563225 | 0.76 | HTR2C (0.58) | HTR2AHTR2CHTR2B | |
| SCHEMBL2017872 | 0.74 | DRD2 (0.41) | SOS1DRD2DRD4DRD1HTR2C | |
| SCHEMBL2015975 | 0.74 | GRIA2 (0.42) | SOS1DRD2DRD3KCNH2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560973-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbvie Inc. (US) | 2013-02-27 | — | — | EP | claimed |
| WO-2011133182-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-10-27 | — | — | WO | claimed |