Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19084436 | 0.80 | MEN1 (0.32) | ADORA2AADORA2BMAPK13EIF2AK2MAPK12 | |
| SCHEMBL25714211 | 0.80 | NOS3 (0.36) | ADORA2AADORA2BMAPK8MAPK9MAPT | |
| SCHEMBL25672732 | 0.80 | DAO (0.33) | ADORA2AADORA2BMAPTKDM4EMAPK13 | |
| SCHEMBL17673728 | 0.78 | NOS3 (0.30) | DAO | |
| SCHEMBL21566642 | 0.77 | ADORA2A (0.37) | ADORA2AADORA2BMAPK8MAPK9MAPT | |
| SCHEMBL12536276 | 0.75 | MAPK13 (0.42) | ADORA2AADORA2BMAPTLMNATP53 | |
| SCHEMBL18540686 | 0.72 | ADORA2A (0.39) | ADORA2AADORA2BMAPK8MAPK9MAPT | |
| SCHEMBL16380219 | 0.71 | ADORA2A (0.42) | ADORA2AADORA2BMAPK8MAPK9MAPT | |
| SCHEMBL12258288 | 0.69 | TSHR (0.43) | ADORA2AADORA2BMAPTLMNATSHR | |
| SCHEMBL18540685 | 0.69 | MAPT (0.38) | ADORA2AADORA2BMAPK8MAPK9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203018-A1 | COVALENT INHIBITORS OF KRAS | ARAXES PHARMA LLC (US) | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203018-A1 | COVALENT INHIBITORS OF KRAS | KRAS, NRAS, HRAS | ADORA2A 3248/4885ADORA2B 1010/4885MAPK8 734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.