Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 11/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 10/20 | 0.37 |
| ▸ | LMNA | P02545 | 8/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24067419 | 0.84 | HSD17B10 (0.40) | CYP3A4CYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL25671290 | 0.82 | CYP3A4 (0.39) | CYP3A4CYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL25670633 | 0.76 | NOTUM (0.36) | CYP19A1 | |
| SCHEMBL24067420 | 0.72 | NCOA3 (0.45) | CYP3A4CYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL25670632 | 0.69 | LMNA (0.40) | LMNAMAPTHSD17B10ALDH1A1KMT2A | |
| SCHEMBL25670579 | 0.67 | PDE5A (0.36) | — | |
| SCHEMBL7649005 | 0.66 | CYP3A4 (0.50) | CYP3A4CYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL20813842 | 0.65 | CYP1A2 (0.42) | CYP3A4CYP1A2CYP2D6CYP2C19LMNA | |
| Hydrochloric Acid SCHEMBL28521741 | 0.65 | CYP3A4 (0.48) | CYP3A4CYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL24067418 | 0.63 | NOTUM (0.35) | HSD17B10ALDH1A1KDM4EHPGDCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11707471-B2 | ENPP1 inhibitors and their use for the treatment of cancer | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2023-07-25 | — | — | US | disclosed |
| US-11701371-B2 | ENPP1 inhibitors and their use for the treatment of cancer | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2023-07-18 | — | — | US | disclosed |
| US-20230190927-A1 | ENPP1 INHIBITORS AND METHODS OF MODULATING IMMUNE RESPONSE | CYANA THERAPEUTICS LLC | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11701371-B2 | ENPP1 inhibitors and their use for the treatment of cancer | ENPP1, ENPP3, ENTPD1 | CYP3A4 4454/4885CYP1A2 4507/4885CYP2D6 4382/4885 |
| US-20230190927-A1 | ENPP1 INHIBITORS AND METHODS OF MODULATING IMMUNE RESPONSE | ENPP1, STING1, ENPP3 | CYP3A4 4354/4885CYP1A2 4654/4885CYP2D6 4583/4885 |
| US-11707471-B2 | ENPP1 inhibitors and their use for the treatment of cancer | ENPP1, ENPP3, ENTPD1 | CYP3A4 4454/4885CYP1A2 4507/4885CYP2D6 4382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.