SCHEMBL2567199

SCHEMBL2567199

C=Cc1ccc(N(C)C(=O)O)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.44
HSD17B3 P37058 1/20 0.40
TDP1 Q9NUW8 1/20 0.39
TSHR P16473 1/20 0.39
CYP2A6 P11509 1/20 0.38
CYP2A13 Q16696 1/20 0.38
TAS1R3 Q7RTX0 2/20 0.36
TAS1R1 Q7RTX1 2/20 0.36
RELA Q04206 1/20 0.35
MAPT P10636 3/20 0.35
KMT2A Q03164 3/20 0.35
LMNA P02545 1/20 0.35
GAA P10253 1/20 0.35
HDAC8 Q9BY41 2/20 0.34
APP P05067 1/20 0.34
SMN1; SMN2 Q16637 3/20 0.34
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
HDAC3 O15379 1/20 0.34
HDAC4 P56524 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL946362 0.82 CYP2A6 (0.59) ALDH1A1HSD17B3CYP2A6CYP2A13RELA
SCHEMBL1536837 0.78 TP53 (0.44) ALDH1A1TDP1TSHRMAPTKMT2A
SCHEMBL24221905 0.78 ALDH1A1 (0.46) ALDH1A1HSD17B3TDP1TSHRCYP2A6
SCHEMBL5461453 0.77 KMT2A (0.44) ALDH1A1HSD17B3TAS1R3TAS1R1KMT2A
SCHEMBL11788282 0.76 HDAC1 (0.44) ALDH1A1MAPTKMT2ASMN1; SMN2NPC1
SCHEMBL23751559 0.76 ALDH1A1 (0.50) ALDH1A1HSD17B3CYP2A6CYP2A13RELA
Lactic Acid SCHEMBL11674403 0.76 HSD17B3 (0.49) ALDH1A1HSD17B3CYP2A6CYP2A13RELA
SCHEMBL23751561 0.76 ALDH1A1 (0.50) ALDH1A1HSD17B3CYP2A6CYP2A13RELA
SCHEMBL24141 0.76 ALDH1A1 (0.39) ALDH1A1HSD17B3TDP1TSHRCYP2A6
SCHEMBL6672441 0.75 TAS1R3 (0.40) ALDH1A1HSD17B3TDP1TAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2381967-B1 SYNTHESIS OF 18F-RADIOLABELED STYRYLPYRIDINES FROM TOSYLATE PRECURSORS AND STABLE PHARMACEUTICAL COMPOSITIONS THEREOF AVID RADIOPHARMACEUTICALS INC (US) 2017-01-18 EP disclosed
EP-2381967-A1 SYNTHESIS OF 18F-RADIOLABELED STYRYLPYRIDINES FROM TOSYLATE PRECURSORS AND STABLE PHARMACEUTICAL COMPOSITIONS THEREOF Avid Radiopharmaceuticals, Inc. (US) 2011-11-02 EP disclosed
WO-2010078370-A1 SYNTHESIS OF 18F-RADIOLABELED STYRYLPYRIDINES FROM TOSYLATE PRECURSORS AND STABLE PHARMACEUTICAL COMPOSITIONS THEREOF AVID RADIOPHARMACEUTICALS, INC. (US) 2010-07-08 WO disclosed
US-20100172836-A1 SYNTHESIS OF 18F-RADIOLABELED STYRYLPYRIDINES FROM TOSYLATE PRECURSORS AND STABLE PHARMACEUTICAL COMPOSITIONS THEREOF AVID RADIOPHARMACEUTICALS, INC. (US) 2010-07-08 US disclosed