Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 8/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3288912 | 0.80 | HDAC1 (0.43) | ACEHDAC1HDAC8HDAC6OPRM1 | |
| SCHEMBL2565333 | 0.68 | ACE (0.49) | ACEHDAC1HDAC8HDAC6HPGD | |
| SCHEMBL28353607 | 0.67 | SLC6A3 (0.45) | ACEHDAC1HDAC8HDAC6OPRM1 | |
| SCHEMBL4703615 | 0.65 | ACE (0.47) | ACEHDAC1HDAC8HDAC6OPRM1 | |
| SCHEMBL3288909 | 0.65 | HDAC1 (0.51) | ACEHDAC1HDAC8HDAC6HPGD | |
| SCHEMBL2568143 | 0.64 | HDAC1 (0.56) | ACEHDAC1HDAC8HDAC6HPGD | |
| SCHEMBL12493534 | 0.64 | SLC6A3 (0.47) | ACEHDAC1HDAC8HDAC6OPRM1 | |
| SCHEMBL4703585 | 0.64 | SLC6A3 (0.47) | ACEHDAC1HDAC8HDAC6OPRM1 | |
| SCHEMBL4703584 | 0.64 | SLC6A3 (0.47) | ACEHDAC1HDAC8HDAC6OPRM1 | |
| SCHEMBL6480196 | 0.63 | HDAC1 (0.46) | ACEHDAC1HDAC8HDAC6OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626961-B1 | NOVEL 2-OXO-HETEROCYCLIC COMPOUNDS AND THE PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | KOREA RES INST OF BIOSCIENCE (KR) | 2011-11-02 | — | — | EP | disclosed |