Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2563898 | 0.93 | HDAC1 (0.56) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL2566024 | 0.88 | HDAC1 (0.53) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL2565333 | 0.87 | ACE (0.49) | HDAC1HDAC8HDAC6ITGB3ITGA2B | |
| SCHEMBL12999350 | 0.81 | HDAC1 (0.54) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL2567758 | 0.80 | ALDH1A1 (0.49) | ACE | |
| SCHEMBL2566621 | 0.80 | HDAC1 (0.54) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL7371673 | 0.77 | ITGB3 (0.51) | HDAC1HDAC8HDAC6ITGB3ITGA2B | |
| SCHEMBL2571159 | 0.77 | HDAC1 (0.49) | HDAC1HDAC8HDAC6SIGMAR1 | |
| SCHEMBL17144454 | 0.73 | HDAC1 (0.50) | HDAC1HDAC8HDAC6SIGMAR1ACE | |
| SCHEMBL28353607 | 0.73 | SLC6A3 (0.45) | HDAC1HDAC8HDAC6SIGMAR1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7846963-B2 | 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2010-12-07 | — | — | US | disclosed |
| US-7846963-B2 | 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2010-12-07 | — | — | US | disclosed |
| US-7846963-B2 | 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2010-12-07 | — | — | US | disclosed |
| US-20100286207-A1 | Novel 2-Oxo-Heterocyclic Compounds And The Pharmaceutical Compositions Comprising The Same | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2010-11-11 | — | — | US | disclosed |
| US-20100286207-A1 | Novel 2-Oxo-Heterocyclic Compounds And The Pharmaceutical Compositions Comprising The Same | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2010-11-11 | — | — | US | disclosed |
| US-20100286207-A1 | Novel 2-Oxo-Heterocyclic Compounds And The Pharmaceutical Compositions Comprising The Same | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2010-11-11 | — | — | US | disclosed |
| US-7723376-B2 | 2-oxo-heterocyclic compounds and pharmaceutical compositions | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2010-05-25 | — | — | US | disclosed |
| US-7723376-B2 | 2-oxo-heterocyclic compounds and pharmaceutical compositions | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2010-05-25 | — | — | US | disclosed |
| US-7723376-B2 | 2-oxo-heterocyclic compounds and pharmaceutical compositions | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2010-05-25 | — | — | US | disclosed |
| CN-100467021-C | Use of novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same | KOREA RES INST OF BIOSCIENCE (KR) | 2009-03-11 | — | — | CN | disclosed |
| US-20070167486-A1 | Novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2007-07-19 | — | — | US | disclosed |
| US-20070167486-A1 | Novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2007-07-19 | — | — | US | disclosed |
| US-20070167486-A1 | Novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2007-07-19 | — | — | US | disclosed |
| CN-1822832-A | Use of novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same | KOREA RES INST OF BIOSCIENCE (KR) | 2006-08-23 | — | — | CN | disclosed |
| US-20060173043-A1 | Use of novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2006-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286207-A1 | Novel 2-Oxo-Heterocyclic Compounds And The Pharmaceutical Compositions Comprising The Same | NOD2, BMP2, NOD1 | HDAC1 227/4885HDAC8 1050/4885HDAC6 221/4885 |
| US-20070167486-A1 | Novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same | NOD2, NOD1, BMP2 | HDAC1 215/4885HDAC8 1090/4885HDAC6 247/4885 |
| US-20060173043-A1 | Use of novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same | MALT1, BRCA1, MCL1 | HDAC1 2103/4885HDAC8 3660/4885HDAC6 2337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.