Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PDE8B | O95263 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.33 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3832136 | 0.96 | HSD17B10 (0.38) | HSD17B10POLBSMN1; SMN2USP2 | |
| SCHEMBL2566481 | 0.96 | HSD17B10 (0.38) | HSD17B10POLBSMN1; SMN2USP2 | |
| SCHEMBL2569354 | 0.90 | HSD17B10 (0.32) | HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL3763846 | 0.89 | PDE8B (0.43) | HSD17B10PDE8BHPGDSMN1; SMN2KDM1A | |
| SCHEMBL3635836 | 0.87 | HSD17B10 (0.38) | HSD17B10PDE8BHPGDSMN1; SMN2KDM1A | |
| SCHEMBL2490765 | 0.85 | HSD17B10 (0.43) | HSD17B10PDE8BSMN1; SMN2NPC1 | |
| SCHEMBL29039261 | 0.85 | HSD17B10 (0.43) | HSD17B10PDE8BSMN1; SMN2NPC1 | |
| SCHEMBL3771067 | 0.85 | HSD17B10 (0.43) | HSD17B10PDE8BSMN1; SMN2NPC1 | |
| SCHEMBL30129954 | 0.83 | HSD17B10 (0.37) | HSD17B10POLBPDE8BHPGDSMN1; SMN2 | |
| SCHEMBL25254934 | 0.83 | HSD17B10 (0.36) | HSD17B10POLBHPGDSMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066659-B1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2013-08-28 | — | — | EP | disclosed |
| EP-2383267-A1 | Substituted sulfonamide derivatives | Grünenthal GmbH (DE) | 2011-11-02 | — | — | EP | disclosed |
| EP-2066659-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008040492-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-04-10 | — | — | WO | disclosed |