Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PDE8B | O95263 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14048084 | 0.91 | ATM (0.44) | HSD17B10ATMCHEK2SMN1; SMN2PDE8B | |
| SCHEMBL2567398 | 0.87 | HSD17B10 (0.34) | HSD17B10SMN1; SMN2PDE8BHPGDKDM1A | |
| SCHEMBL2566481 | 0.85 | HSD17B10 (0.38) | HSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL3832136 | 0.85 | HSD17B10 (0.38) | HSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL30129954 | 0.81 | HSD17B10 (0.37) | HSD17B10SMN1; SMN2PDE8BHPGDKDM1A | |
| SCHEMBL3636928 | 0.81 | PARP1 (0.46) | FKBP1A | |
| SCHEMBL3763846 | 0.79 | PDE8B (0.43) | HSD17B10ATMCHEK2SMN1; SMN2PDE8B | |
| SCHEMBL25254934 | 0.78 | HSD17B10 (0.36) | HSD17B10SMN1; SMN2HPGDALDH1A1NPC1 | |
| SCHEMBL25426577 | 0.78 | HSD17B10 (0.34) | HSD17B10SMN1; SMN2 | |
| SCHEMBL25426575 | 0.78 | HSD17B10 (0.34) | HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155678-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC Neurosciences GmbH (DE) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008125570-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2008-10-23 | — | — | WO | disclosed |