Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 11/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2562274 | 0.83 | PRSS1 (0.57) | F2PLAUST14PRSS1 | |
| SCHEMBL2563466 | 0.79 | PTPN11 (0.53) | PRSS1HPGDMAPTHSD17B10 | |
| SCHEMBL2568322 | 0.76 | SMN1; SMN2 (0.59) | F2PLAUST14PRSS1HPGD | |
| SCHEMBL16198787 | 0.75 | GAA (0.53) | HDAC1HDAC8HDAC6HPGDKDM4E | |
| SCHEMBL2567834 | 0.75 | KDM4E (0.44) | F2PLAUST14PRSS1HPGD | |
| SCHEMBL7962802 | 0.74 | HTR2C (0.46) | PRSS1HPGDKDM4ENPC1LMNA | |
| SCHEMBL7961007 | 0.74 | HTR2B (0.46) | F2PLAUST14HDAC6PRSS1 | |
| SCHEMBL7962020 | 0.72 | PRSS1 (0.47) | PRSS1HPGDKDM4ENPC1LMNA | |
| Hydrochloric Acid SCHEMBL11629258 | 0.71 | PRSS1 (0.48) | PRSS1HPGDKDM4ENPC1LMNA | |
| SCHEMBL9850680 | 0.70 | SLC6A9 (0.41) | PRSS1HPGDKDM4ENPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2383262-B1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | TOPHARMAN SHANGHAI CO LTD (CN) | 2016-07-06 | — | — | EP | disclosed |
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| EP-2383262-A1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | Topharman Shanghai Co., Ltd. (CN) | 2011-11-02 | — | — | EP | disclosed |