Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | CCR5 | P51681 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17040591 | 0.87 | TSHR (0.49) | HTR2CHTR2BMAPTCCR5LMNA | |
| Hydrochloric Acid SCHEMBL11629080 | 0.86 | TSHR (0.48) | HTR2CHTR2BMAPTCCR5LMNA | |
| SCHEMBL7951291 | 0.84 | HTR2B (0.50) | HTR2CHTR2BCSNK2A1MAPTKDM4E | |
| SCHEMBL2562274 | 0.83 | PRSS1 (0.57) | PRSS1 | |
| SCHEMBL2567834 | 0.83 | KDM4E (0.44) | CSNK2A1MAPTKDM4ENPC1LMNA | |
| SCHEMBL16959814 | 0.82 | L3MBTL1 (0.48) | HTR2CHTR2BCSNK2A1MAPTPKM | |
| SCHEMBL7961007 | 0.81 | HTR2B (0.46) | HTR2CHTR2BCSNK2A1MAPTKDM4E | |
| SCHEMBL2568322 | 0.81 | SMN1; SMN2 (0.59) | MAPTKDM4ECCR5NPC1LMNA | |
| SCHEMBL7962020 | 0.80 | PRSS1 (0.47) | MAPTKDM4ENPC1LMNAHPGD | |
| SCHEMBL20522075 | 0.79 | GAA (0.61) | MAPTPKML3MBTL1LMNAPTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200980-B1 | ADMINISTERING PHENYL PURINONE COMPOUND FOR TREATING PRECANCEROUS LEISONS | CELL PATHWAYS, INC. | 2001-03-13 | — | — | US | disclosed |
| EP-0352960-B1 | Purine compounds, process for their preparation and pharmaceutical compositions | SMITH KLINE FRENCH LAB (GB) | 1994-10-26 | — | — | EP | disclosed |
| US-5073559-A | 2-Substituted purinone having phosphodiesterase inhibitory activity | SMITH KLINE & FRENCH LABORATORIES, LTD. (GB) | 1991-12-17 | — | — | US | disclosed |
| EP-0352960-A2 | Purine compounds, process for their preparation and pharmaceutical compositions | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-01-31 | — | — | EP | disclosed |