Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1225933 | 0.91 | TSHR (0.44) | TSHRALDH1A1CYP3A4RECQLTDP1 | |
| SCHEMBL1226651 | 0.84 | TSHR (0.40) | TSHRALDH1A1CYP3A4TDP1MAPT | |
| SCHEMBL6484011 | 0.83 | LMNA (0.42) | TSHRALDH1A1CYP3A4TDP1MAPT | |
| SCHEMBL15938731 | 0.80 | ALDH1A1 (0.45) | TSHRALDH1A1CYP3A4RECQLTDP1 | |
| SCHEMBL2443339 | 0.79 | TSHR (0.51) | TSHRALDH1A1CYP3A4RECQLTDP1 | |
| SCHEMBL5521904 | 0.78 | TDP1 (0.44) | TSHRALDH1A1CYP3A4RECQLTDP1 | |
| SCHEMBL21067054 | 0.77 | ALDH1A1 (0.40) | TSHRALDH1A1CYP3A4RECQLTDP1 | |
| SCHEMBL28521194 | 0.77 | TSHR (0.42) | TSHRALDH1A1CYP3A4RECQLTDP1 | |
| SCHEMBL30640048 | 0.77 | ALDH1A1 (0.40) | TSHRALDH1A1CYP3A4RECQLTDP1 | |
| SCHEMBL3139080 | 0.76 | TSHR (0.52) | TSHRALDH1A1CYP3A4RECQLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382202-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010072607-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-07-01 | — | — | WO | disclosed |