Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.55 |
| ▸ | JAK1 | P23458 | 9/20 | 0.55 |
| ▸ | TYK2 | P29597 | 9/20 | 0.55 |
| ▸ | JAK3 | P52333 | 9/20 | 0.55 |
| ▸ | HRH1 | P35367 | 3/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25679745 | 0.81 | HRH1 (0.48) | JAK2JAK1TYK2JAK3HRH1 | |
| SCHEMBL25679737 | 0.79 | KDM4E (0.57) | HRH1USP2KDM4EALDH1A1MAPT | |
| SCHEMBL25218469 | 0.75 | HRH1 (0.45) | JAK2JAK1TYK2JAK3HRH1 | |
| SCHEMBL30533988 | 0.75 | HRH1 (0.45) | JAK2JAK1TYK2JAK3HRH1 | |
| SCHEMBL30533963 | 0.75 | CCNK (0.39) | JAK2JAK1TYK2JAK3HRH1 | |
| SCHEMBL25221756 | 0.75 | CCNK (0.39) | JAK2JAK1TYK2JAK3HRH1 | |
| SCHEMBL25678221 | 0.75 | ALDH1A1 (0.53) | JAK2JAK1TYK2JAK3USP2 | |
| SCHEMBL24166159 | 0.71 | KMT2A (0.52) | HRH1POLBKDM4EALDH1A1 | |
| SCHEMBL30656807 | 0.71 | KMT2A (0.52) | HRH1POLBKDM4EALDH1A1 | |
| SCHEMBL17888855 | 0.70 | HRH1 (1.00) | HRH1CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203010-A1 | BICYCLIC AMINE CDK12 INHIBITORS | INCYTE CORPORATION | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203010-A1 | BICYCLIC AMINE CDK12 INHIBITORS | CDK12, CDK1, CDK2 | JAK2 424/4885JAK1 856/4885TYK2 413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.