Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | JAK2 | O60674 | 4/20 | 0.41 |
| ▸ | JAK1 | P23458 | 4/20 | 0.41 |
| ▸ | TYK2 | P29597 | 4/20 | 0.41 |
| ▸ | JAK3 | P52333 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25218469 | 1.00 | HRH1 (0.45) | HRH1KMT2AJAK2JAK1TYK2 | |
| SCHEMBL25259362 | 0.81 | ALDH1A1 (0.48) | KMT2AMEN1PKMOPRM1ALDH1A1 | |
| SCHEMBL30464366 | 0.77 | CCNK (0.36) | HRH1KMT2AMEN1PKMOPRM1 | |
| SCHEMBL25258833 | 0.77 | CCNK (0.36) | HRH1KMT2AMEN1PKMOPRM1 | |
| SCHEMBL25679715 | 0.75 | JAK2 (0.55) | HRH1JAK2JAK1TYK2JAK3 | |
| SCHEMBL25679745 | 0.68 | HRH1 (0.48) | HRH1JAK2JAK1TYK2JAK3 | |
| SCHEMBL3566734 | 0.66 | ALDH1A1 (0.54) | KMT2AMEN1PKMALDH1A1CYP2D6 | |
| SCHEMBL14447529 | 0.65 | RAB9A (0.44) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL31735444 | 0.65 | MEN1 (0.46) | KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL26758112 | 0.64 | MEN1 (0.48) | KMT2AMEN1ALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102184-A1 | BICYCLIC AMINE COMPOUNDS AS CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-06-08 | — | — | WO | disclosed |