Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTSR1 | P30989 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 3/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | MARK3 | P27448 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24015771 | 0.83 | NTSR1 (0.50) | NTSR1MAPK1SMN1; SMN2PDE4APDE4D | |
| SCHEMBL29589930 | 0.81 | ENPP1 (0.51) | NTSR1MAPK1SMN1; SMN2PDE4APDE4D | |
| SCHEMBL20813450 | 0.81 | NTSR1 (0.49) | NTSR1MAPK1SMN1; SMN2PDE4APDE4D | |
| SCHEMBL14115083 | 0.81 | HTT (0.54) | MAPK1SMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL15819368 | 0.81 | ENPP1 (0.51) | NTSR1MAPK1SMN1; SMN2PDE4APDE4D | |
| SCHEMBL15819106 | 0.81 | NTSR1 (0.49) | NTSR1MAPK1SMN1; SMN2PDE4APDE4D | |
| SCHEMBL24067384 | 0.79 | NTSR1 (0.47) | NTSR1MAPK1SMN1; SMN2PDE4APDE4D | |
| SCHEMBL24392105 | 0.79 | NTSR1 (0.47) | NTSR1MAPK1SMN1; SMN2PDE4APDE4D | |
| SCHEMBL24392653 | 0.76 | NTSR1 (0.50) | NTSR1KDM4EALDH1A1MAPTPDE3B | |
| SCHEMBL24391771 | 0.74 | EHMT2 (0.53) | NTSR1KDM4EALDH1A1MAPTPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183239-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF | ABBVIE INC (US) | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183239-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF | ENPP1, ENPP3, STING1 | NTSR1 2753/4885MAPK1 2004/4885SMN1; SMN2 3306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.