Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.58 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1161620 | 0.76 | PSMB8 (0.47) | PRMT5PSMB8KDM4EALDH1A1LMNA | |
| SCHEMBL5457312 | 0.75 | PRMT5 (0.66) | PRMT5KDM4EALDH1A1GAATLR8 | |
| SCHEMBL25175074 | 0.74 | PRMT5 (0.37) | PRMT5KDM4EALDH1A1GAATSHR | |
| SCHEMBL25167934 | 0.74 | TLR8 (0.36) | PRMT5KDM4EALDH1A1GAATLR8 | |
| SCHEMBL31258624 | 0.74 | TLR8 (0.36) | PRMT5KDM4EALDH1A1GAATLR8 | |
| SCHEMBL5104145 | 0.74 | PRMT5 (1.00) | PRMT5PSMB8KDM4EGAATLR8 | |
| SCHEMBL5448072 | 0.74 | PRMT5 (0.64) | PRMT5PSMB8KDM4ETLR8POLB | |
| SCHEMBL31258646 | 0.73 | LTB4R (0.45) | PRMT5KDM4EALDH1A1GAATLR8 | |
| SCHEMBL25168462 | 0.73 | LTB4R (0.45) | PRMT5KDM4EALDH1A1GAATLR8 | |
| Hydrochloric Acid SCHEMBL25175077 | 0.72 | LTB4R (0.44) | PRMT5KDM4EALDH1A1GAATLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081367-A2 | 2-AMINO IMIDAZOLE DERIVATIVES | Mirati Therapeutics, Inc. (US) | 2023-05-11 | — | — | WO | disclosed |