Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | HRH2 | P25021 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | HTR5A | P47898 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | OGA | O60502 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3992996 | 0.79 | HRH4 (0.57) | HRH4HRH3HTR6HSD17B10TSHR | |
| SCHEMBL15360086 | 0.76 | HRH4 (0.70) | HRH4HRH3ADRA2BADRA2CSLC6A2 | |
| SCHEMBL7994849 | 0.75 | EPHX2 (0.50) | ALDH1A1HSD17B10TSHR | |
| SCHEMBL19506859 | 0.74 | HRH4 (0.56) | HRH4SIGMAR1 | |
| SCHEMBL848216 | 0.74 | HRH4 (0.56) | HRH4SIGMAR1 | |
| SCHEMBL1589120 | 0.74 | HRH4 (0.89) | HRH4HRH3ADRA2BADRA2CSLC6A2 | |
| SCHEMBL19233159 | 0.74 | HRH4 (1.00) | HRH4HRH3ADRA2BADRA2CSLC6A2 | |
| SCHEMBL1588422 | 0.74 | HRH4 (1.00) | HRH4HRH3ADRA2BADRA2CSLC6A2 | |
| Hydrochloric Acid SCHEMBL7984877 | 0.74 | EPHX2 (0.49) | ALDH1A1HSD17B10TSHR | |
| SCHEMBL1588697 | 0.72 | HRH4 (1.00) | HRH4HRH3ADRA2BADRA2CSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382013-A1 | SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS. | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010072829-A1 | SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS. | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2010-07-01 | — | — | WO | disclosed |