Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK3 | P07288 | 7/20 | 0.64 |
| ▸ | ABL1 | P00519 | 3/20 | 0.59 |
| ▸ | BCR | P11274 | 3/20 | 0.59 |
| ▸ | TEK | Q02763 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | F12 | P00748 | 3/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KLK14 | Q9P0G3 | 1/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.44 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2571839 | 0.89 | KLK3 (0.66) | KLK3ABL1BCRHDAC1F12 | |
| SCHEMBL2567843 | 0.83 | KLK3 (0.67) | KLK3HDAC1F12F2MAPT | |
| SCHEMBL14688962 | 0.79 | MAPT (0.56) | ABL1BCRTEKF2MAPT | |
| SCHEMBL2561567 | 0.79 | KLK3 (0.56) | KLK3F12F2MAPTKLK7 | |
| SCHEMBL2562182 | 0.75 | F2 (0.52) | ABL1BCRTEKF2MAPT | |
| SCHEMBL2551224 | 0.72 | MAPT (0.78) | F2MAPTKMT2ALMNA | |
| SCHEMBL2551230 | 0.72 | KLK3 (0.52) | KLK3F12F2MAPTKMT2A | |
| SCHEMBL2567005 | 0.70 | F2 (0.58) | F2MAPTKMT2ALMNA | |
| SCHEMBL2689845 | 0.69 | CYP2A6 (0.54) | KLK3 | |
| SCHEMBL3791243 | 0.69 | FYN (0.67) | ABL1BCRATRFYNKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560966-A2 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | Verseon Corporation (US) | 2013-02-27 | — | — | EP | disclosed |
| WO-2011126903-A2 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN | VERSEON, INC. (US) | 2011-10-13 | — | — | WO | disclosed |