Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 10/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.57 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.57 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2557436 | 0.90 | TTK (0.52) | TTKPDPK1MAP3K5LRRK2MAPK8 | |
| SCHEMBL2563513 | 0.88 | TTK (0.74) | TTKMAPK8MAP2K4 | |
| Hydrochloric Acid SCHEMBL2557647 | 0.87 | TTK (0.73) | TTKMAPK8MAP2K4 | |
| SCHEMBL922900 | 0.81 | JAK2 (0.70) | TTKPDPK1MAP3K5LRRK2PLK4 | |
| SCHEMBL2570707 | 0.81 | MAPK1 (0.57) | TTKPDPK1MAP3K5LRRK2MAP2K4 | |
| Trifluoroacetic Acid SCHEMBL2555732 | 0.79 | TTK (0.65) | TTKMAPK8MAP2K4 | |
| SCHEMBL31423230 | 0.77 | DCLK1 (0.65) | TTKLRRK2AURKAMAP2K4AXL | |
| SCHEMBL4008208 | 0.77 | DCLK1 (0.65) | TTKLRRK2AURKAMAP2K4AXL | |
| SCHEMBL22890746 | 0.76 | AURKA (0.52) | TTKPDPK1LRRK2MAPK8AURKA | |
| SCHEMBL29644074 | 0.76 | AURKA (0.52) | TTKPDPK1LRRK2MAPK8AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |