Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3628875 | 0.94 | DPP4 (0.40) | DPP4DPP7VNN1ALDH1A1RIPK1 | |
| SCHEMBL4830838 | 0.85 | DPP4 (0.46) | DPP4DPP7RIPK1GRM5 | |
| SCHEMBL31143152 | 0.79 | DPP4 (0.39) | DPP4DPP7VNN1ALDH1A1RIPK1 | |
| SCHEMBL24242889 | 0.78 | ALDH1A1 (0.54) | DPP4DPP7KMT2AMEN1VNN1 | |
| SCHEMBL23144924 | 0.77 | ALDH1A1 (0.41) | DPP4DPP7KMT2AMEN1VNN1 | |
| SCHEMBL3628873 | 0.77 | VNN1 (0.42) | DPP4DPP7VNN1ALDH1A1RIPK1 | |
| SCHEMBL1125850 | 0.77 | DPP4 (0.37) | DPP4DPP7KMT2AMEN1VNN1 | |
| SCHEMBL10279141 | 0.75 | CYP3A4 (0.43) | DPP4DPP7KMT2AMEN1VNN1 | |
| SCHEMBL13163969 | 0.75 | DPP4 (0.42) | DPP4DPP7VNN1ALDH1A1RIPK1 | |
| SCHEMBL31616276 | 0.75 | GRM5 (0.45) | ALDH1A1HSD11B1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2384328-A1 | 6,7,8,9-TETRAHYDRO-5H-1,4,7,10A-TETRAAZA-CYCLOHEPT[F]INDENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR PREPARING THEM | Boehringer Ingelheim International GmbH (DE) | 2011-11-09 | — | — | EP | disclosed |
| WO-2010060952-A1 | 6,7,8,9-TETRAHYDRO-5H-1,4,7,10A-TETRAAZA-CYCLOHEPT[F]INDENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-06-03 | — | — | WO | disclosed |