Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15258744 | 0.83 | OPRM1 (0.45) | OPRM1OPRL1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL16015556 | 0.79 | OPRM1 (0.43) | OPRM1OPRL1ALDH1A1MAPTAKR1C1 | |
| SCHEMBL19647226 | 0.76 | OPRM1 (0.41) | OPRM1OPRL1ALDH1A1MAPTAKR1C1 | |
| SCHEMBL19647052 | 0.76 | OPRM1 (0.41) | OPRM1OPRL1ALDH1A1MAPTAKR1C1 | |
| SCHEMBL19647087 | 0.74 | AKR1C1 (0.40) | OPRM1OPRL1ALDH1A1AKR1C1HDAC4 | |
| SCHEMBL27742157 | 0.73 | AKR1C1 (0.42) | OPRM1OPRL1ALDH1A1AKR1C1HDAC4 | |
| SCHEMBL11047935 | 0.73 | OPRM1 (0.45) | OPRM1OPRL1AKR1C1HDAC4OPRK1 | |
| SCHEMBL6670890 | 0.73 | HDAC4 (0.42) | OPRM1OPRL1ALDH1A1POLBAKR1C1 | |
| SCHEMBL17215183 | 0.70 | AKR1C1 (0.40) | OPRM1OPRL1ALDH1A1AKR1C1HDAC4 | |
| SCHEMBL14899045 | 0.70 | AKR1C1 (0.48) | OPRM1OPRL1ALDH1A1AKR1C1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382205-B1 | DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF AS HIF ACTIVATORS | SANOFI SA (FR) | 2014-04-23 | — | — | EP | disclosed |
| EP-2382205-A2 | DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF AS HIF ACTIVATORS | SANOFI (FR) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010076524-A2 | DERIVATIVES OF 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, PREPARATION AND THERAPEUTIC USE THEREOF AS HIF ACTIVATORS | SANOFI-AVENTIS (FR) | 2010-07-08 | — | — | WO | disclosed |